P533 Relation between TL1A expression in intestinal mucosa, and endoscopic severity and clinical course in ulcerative colitis

Abstract Background TL1A is a TNF super family member cytokine encoded by TNFSF15 and reported to be disease susceptibility gene for IBD. The relationship between expression IBD pathophysiology, clinical course, endoscopic findings was not sufficiently clear. aim of this study clarify the correlation in intestinal mucosa UC severity, course. Methods subjects were patients with who visiting our hospital. Mucosal samples biopsied from rectum lower gastrointestinal endoscopy, examined RT-PCR. We analyzed patients’ background, symptoms, blood test findings, mucosal activity expression. Results A total 77 specimens obtained individual colonoscopy 61 cases included. Median age 43, 36 males, duration 2 years, number pancolitis 54, median partial mayo score (pMayo) 3, level CRP 1.5 mg/L. Mayo subscore (MES) 0, 1, 2, 3 14, 27, 24, 12, respectively, mean 1.76-, 1.09-, 1.17-times higher MES than respectively. significantly 1 0 2. active group (pMayo 4 or higher) compared clinically low lower). ≥0.03 <0.03. those at initial onset 3. Eight before after induction therapy, increased 1.9-fold therapy. No found use biologics small molecular compounds TL1A. Conclusion Relatively revealed known secreted various cell types such as macrophages lymphocytes. It suggested that source amount would alter according degree inflammation.